Abstract
A novel hydrophobic organic–inorganic hybrid nanocomposite was prepared for sustained release of analgesic. Using enlarged halloysite nanotubes (EHNTs) as nanocontainer and organosilane (OS) as the hydrophobic layer, nanocomposite denote as [email protected] was readily prepared with a mild reaction. Then the [email protected] was characterized by Fourier transform infrared spectroscopy, transmission electron microscopy, energy dispersive X-ray analysis, and high-performance liquid chromatography. The hydrophobic layer composed of tetraethoxysilane and octyltriethoxysilane made a difference on the wettability of the [email protected] It was proved that the nanocomposite exhibited excellent hydrophobicity with a water contact angle of 132°. Moreover, an enhanced capacity for adsorption (25%) and the sustained-release performance (100 h) of the [email protected] toward IBU were demonstrated and it followed the power law kinetic model. In conclusion, the drug-release platform explored in this work is suitable for other drugs and shows further comprehensive application prospect.
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