Abstract
In this study, biomimetic 3D porous hybrid scaffolds were prepared from GC matrix with subsequent doping of SeHA and GaHA nanocrystals through a bioinspired wet-chemical precipitation method. The concentration of Se and Ga ions varied with Se/P and Ga/Ca molar ratio of 1 mol.%, 2.5 mol.% and 5 mol.%. The physicochemical evaluation showed that the scaffolds were hydrophilic, biodegradable and exhibited a porous network. The combined analytical results clearly show that both Se and Ga ions were successfully nucleated along the HA nanocrystals. All the scaffold groups were calcium deficient and non-hemolytic with profound anti-infection properties. Cytocompatibility results showed that both GC-SeHA and GC-GaHA scaffolds had cell recognition functions offering selective cytotoxicity to cancer cells but not towards normal cells with the ability to induce angiogenesis. To conclude, Se and Ga concentration below 2.5 mol.% can provide good morphological and crystallographic features with tunable mechanical, antibacterial and osteogenic properties.
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