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Abstract
The blood-brain barrier (BBB) maintains the homeostasis between the central nervous system and the blood circulation [1]. One of the main efflux transporter proteins at the BBB is P-glycoprotein (P-gP) also known as ABCB1 or MDR1. Recently, transport studies with antidepressants suggested presence and functional activity of P-gP in an in vitro model of the BBB based on porcine cell line PBMEC/C1-2 [2]. Due to the important role of P-gP for the transport barrier function of the BBB, the presence and functionability of P-gP was investigated in cell line PBMEC/C1-2 maybe leading to an in vitro BBB model suitable for P-gP substrate screening.
Highlights
The blood-brain barrier (BBB) maintains the homeostasis between the central nervous system and the blood circulation [1]
Transport studies with antidepressants suggested presence and functional activity of P-gP in an in vitro model of the BBB based on porcine cell line PBMEC/C1-2 [2]
Due to the important role of P-gP for the transport barrier function of the BBB, the presence and functionability of P-gP was investigated in cell line PBMEC/C1-2 maybe leading to an in vitro BBB model suitable for PgP substrate screening
Summary
The blood-brain barrier (BBB) maintains the homeostasis between the central nervous system and the blood circulation [1]. Functionality of P-glycoprotein in the Blood-Brain Barrier Mimicking Cell Line PBMEC/C1-2 Austria 2 Department of Medicinal Chemistry, University of Vienna, Althanstraße 14, 1090
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