Abstract
Functionality of GalenIQ 721 as excipient for direct compression tabletsSonia Cecilia Barrios-Vazquezand Leopoldo Villafuerte-Robles
Highlights
The functional performance of tablet excipients is related to their physical, chemical and technological properties
Materials The materials used in this study were Carbopol 971P NF, obtained from Lubrizol, CDMX (MEXICO); Hydroxypropyl methylcellulose (HPMC), Benecel K4M, obtained from Ashland Specialty Ingredients, CDMX (MEXICO); metronidazole obtained from Química Alkano, CDMX (MEXICO)
The use of polymers such as Carbopol 971P NF and Benecel K4M display drug release mechanisms where water molecules tend to diffuse into these systems causing swelling which results in diffusion of drug molecules out through the swollen polymeric matrix
Summary
The functional performance of tablet excipients is related to their physical, chemical and technological properties. The functional performance of excipients to control the release from drug delivery systems allows the knowledge of their possible uses (Villafuerte-Robles, 2011).Agents to control the release of drug from a tablet ideally provide the property to modulate the dissolution rate, and improve the flow properties of the powders and the compactibility. Hydroxypropyl methylcellulose (HPMC) is a polymer that improves powder system flowability while maintaining compressibility, tablet hardness, and controlled release performance. It helps improve processing speed and predictable and consistent drug release profiles (Introducing Methocel, 2008). Dissolution profiles of niacin from tablets containing different batches of HPMC showed values of the exponent n ranging from 0.69 to 0.76, indicating combined drug release mechanisms of diffusion and dissolution/erosion of the polymer (Zhou et al, 2014)
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