Abstract
Carboxylated multiwall carbon nanotubes (MWCNT-COOH) were first modified by thiourea to form an MWCNT-amide and then by 2-bromoacetophenone to produce MWCNT-thiazole. All samples were characterised by Fourier transform infrared spectroscopy, Raman spectroscopy, scanning electron microscope, energy dispersive X-ray spectroscopy and thermogravimetric analysis. These functionalisations have been chosen due to the active sites of C = S and amine groups in MWCNT-amide, which might be used as functional materials in the future. Toxicity of these samples was evaluated with human embryonic kidney (HEK293) and human breast cancer (SKBR3) cell lines, and the viable cell numbers were measured by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl tetrazolium bromide (MTT) after culturing cells for 24 h. Cellular investigations showed that the modified MWCNTs have considerably significant toxic impact on SKBR3 as compared to HEK293 at concentrations 4 to 5 μg mL− 1.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.