Abstract
The nature of the tolerance that develops to the sedative action of lorazepam was investigated using a hole-board apparatus. Rats treated with lorazepam (0.125, 0.25 and 0.50 mg/kg) once daily for 3 days showed similar degrees of tolerance to the effects of a test dose of 0.25 mg/kg lorazepam. Tolerance was also observed in animals treated once every 2 days with lorazepam (0.50 mg/kg). Measurement of the plasma and brain concentrations of lorazepam immediately after the behavioural test showed that this tolerance was functional and not dispositional. In contrast, the behavioural effects of lorazepam were not reduced as a result of 3 days of treatment with a sedative dose of sodium pentobarbitone (20 mg/kg), although this led to lower brain concentrations of lorazepam at the time of testing.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
