Functional thalamocortical connectivity development and alterations in preterm infants during the neonatal period

Abstract

The thalamus is one of the most commonly affected brain regions in preterm infants, particularly in infants with white matter lesions (WML). The aim of this paper is to explore the development and alterations of the functional thalamocortical connectivity in preterm infants with and without punctate white matter lesions (PWMLs) during the period before term equivalent age (TEA). In this study, twenty-two normal preterm infants (NP), twenty-two preterm infants with PWMLs and thirty-one full-term control infants (FT) were enrolled. Thalamus parcellation was performed based on partial correlation between the thalamus and seven well-recognized infant networks obtained from independent component analysis (ICA), and thalamocortical connectivity was further reconstructed between the defined thalamus clusters and the whole brain. Thalamo-salience (SA) and thalamo-sensorimotor (SM) connectivity were predominantly identified, while other types of thalamocortical connectivity remained largely limited during the neonatal period. Both preterm groups exhibited prominent development in thalamo-SA and thalamo-SM connectivity during this period. Compared with NP infants, PWML infants demonstrated increased connectivity in the parietal area in thalamo-SA connectivity but no significant differences in thalamo-SM connectivity. Our results reveal that compared with NP infants, PWML infants exhibit slightly altered thalamo-SA connectivity, and this alteration is deduced to be functional compensations for inefficient thalamocortical processing due to PWMLs.