Functional STK15 Phe31Ile and p53 Pro72arg Polymorphism and Bladder Cancer in Southwestern Taiwan

Abstract

PP-31-172 Background/Aims: To evaluate whether arsenic exposure and functional STK15 (Aurora A) Phe31Ile and p53 Pro72Arg polymorphisms are associated with the risk of bladder cancer in southwestern Taiwan. Methods: We conducted a hospital-based case-control study and recruited bladder cancer patients as cases and noncancer patients as controls. All the participants were interviewed using a standard questionnaire to collect relevant data. The genotypes were determined using polymerase chain reaction-restricted fragment length polymorphism. Results: We recruited 59 bladder cancer patients and 201 controls. We found that male gender, lower educational level, and cigarette smoking were associated with a higher risk of bladder cancers. In addition, we found that drinking well water over 15 years and in southwestern Taiwan with high arsenic concentration were also risk factors of bladder cancer. In the gene polymorphism analysis, we found that both STK15 Phe31Ile (T > A) mutant type (AA) and mutant allele (A) associated with a higher risk of bladder cancer (OR = 2.1, 95% CI: 0.8–5.5, P = 0.39) and (OR = 1.7, 95% CI: 0.7–4.4, P = 0.17), but the increases were not statistically significant. p53 Pro72Arg (C > G) with one mutant allele (GC) was associated with a higher risk of bladder cancer (OR: 1.4, 95% CI: 0.7–2.7, P = 0.54), but the increase was not statistically significant, either. Regardless of genotypes, an increase in arsenic exposure was associated with a significant higher risk of bladder cancers. Conclusion: Arsenic exposure was associated with a higher risk of bladder cancers, but the effects of STK15 Phe31Ile and p53 Pro72Arg polymorphisms on bladder cancer were not statistically significant.