Abstract
High use of CPAP increased weight more than high use sham (1.4 kg; 0.04—2.9, p = 0.05) and more than low CPAP use (1.6 kg; 0.4—2.8, p = 0.01). There was no difference between high and low sham users (0.36 kg;−1.0 to 1.7, NS). Neither treatment alone, CPAP dose alone nor the combined effect of both influenced glucose, insulin or insulin resistance. Conclusion: High use CPAP increases weight compared to high use sham and low use CPAP without any subsequent changes in metabolic dysfunction. It is possible an increase in lean muscle mass rather than fat is the cause of the weight gain which may not necessarily have a detrimental effect on health.
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