Functional roles of long non-coding RNA in human breast cancer.

Ni Ye,Rui Wu,Qi-Gui Yan,Zi-Fang Quan,Bin Wang,Xiao-Ping Ma,San-Jie Cao,Xin-Tian Wen,Xiao-Bo Huang,Yong Huang

doi:10.7314/apjcp.2014.15.15.5993

Abstract

The discovery of long noncoding RNA (LncRNA) changes our view of transcriptional and posttranscriptional regulation of gene expression. With application of new research techniques such as high-throughput sequencing, the biological functions of LncRNAs are gradually becoming to be understood. Multiple studies have shown that LncRNAs serve as carcinogenic factors or tumor suppressors in breast cancer with abnormal expression, prompts the question of whether they have potential value in predicting the stages and survival rate of breast cancer patients, and also as therapeutic targets. Focusing on the latest research data, this review mainly summarizes the tumorigenic mechanisms of certain LncRNAs in breast cancer, in order to provide a theoretical basis for finding safer, more effective treatment of breast cancer at the LncRNA molecular level.

Highlights

Breast cancer occurs in mammary gland epithelial tissue, 99 % of breast cancer in women, only 1 % of men
Focusing on the latest research data, this review mainly summarizes the tumorigenic mechanisms of certain long noncoding RNA (LncRNA) in breast cancer, in order to provide a theoretical basis for finding safer, more effective treatment of breast cancer at the LncRNA molecular level
We summarize mainly biological functions of LncRNA including mediated by miRNAs and functional role of some certain LncRNAs which involved in breast cancer as oncogenes or tumor suppressor genes, so as to provide theoretical basis for College of Veterinary Medicine, Sichuan Agricultural University, Yaan, Sichuan, China *For correspondence: yanqigui@126.com

Summary

Introduction

Breast cancer occurs in mammary gland epithelial tissue, 99 % of breast cancer in women, only 1 % of men. Mammary gland is not the important organs to maintain life and the situ breast cancer is not fatal, but the connection between the breast cancer cells is loose and cells fall off forming cancer metastasis though the blood and lymph which imperil patient’s life. With technology advance, such as highthroughput sequencing, microarray, let scientists have a deeper understanding of molecular biology, especially non-coding RNA. LncRNA with an abnormal expression in multiple tumors show they could act as an important role in corresponding cancer

RNA and Cancer

Findings

Conclusions