Abstract
Functional role of polyphenol rich butanol fraction of Rivea ornata in experimentally induced myocardial infarction: Preservation of Cell viability and Free radical neutralization
Highlights
Interruption of coronary blood flow partially or completely to a portion of the myocardium over the threshold result in to infraction
Observations like Electrocardiogram, infarction markers (Lactate dehydrogenase, Creatine kinase-MB, C-reactive protein), Sodium–potassium adenosine triphosphatase and Calcium adenosine triphosphatase, oxidative stress markers [Catalase (CAT), Superoxide dismutase (SOD), Reduced glutathione (GSH) & Malondialdehyde (MDA)], inflammation markers Tumour Necrosis Factor alpha (TNF-α), Interleukins (IL-6 & 10) and histopathological examinations were performed in all groups
According to statement given by World Health Organization (WHO), highest mortality rate is accounted by the ischemic heart diseases (Aronow, 2006; Patel et al, 2010)
Summary
Interruption of coronary blood flow partially or completely to a portion of the myocardium over the threshold result in to infraction. Despite modern medicines are widely used to treat cardiovascular diseases but its cost, side effects, availability, people are looking in to traditional and complementary medicines has been increased to preventive medicine of human diseases (Adenipekun et al, 2018). Bioactive phytochemicals such as polyphenols, flavonoids, tannins, anthocyanins rich fruits, vegetable, Sudheer et al / Journal of Applied Pharmaceutical Science 11 (06); 2021: 094-104 in preventing of heart diseases (Brewer, 2011; Speer et al, 2020). We try to create scientific evidence for its protective capacity by rodent model myocardial infarction (MI)
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