Functional role of new striatopallidal specific genes in motor and motivational behavior

Abstract

Event Abstract Back to Event Functional role of new striatopallidal specific genes in motor and motivational behavior Deniz Karadurmus1*, Daniel Rial1, Alban De Kerchove D'Exaerde1 and Serge N. Schiffmann1 1 Université Libre de Bruxelles, Belgium Basal ganglia are a set of interconnected nuclei involved in motor control and motivation. The striatum is the main input of basal ganglia and is mainly composed of medium spiny neurons, subdivided into striatopallidal (STP) and striatonigral (STN) neurons. STP and STN neurons give rise respectively to the indirect and the direct pathways of basal ganglia, with opposite effects at both motor and motivational levels. Cellular mechanisms involving these pathways in disorders such as Huntington's and Parkinson's diseases and addiction, are still poorly understood. Our laboratory has previously identified gene expression profiles of STN and STP neurons using microarray (Ena et al., 2013). The present work consists in the identification and functional study of genes differentially expressed in STN and STP neurons, selected on their potential involvement in striatal functions. Using floxed mice, shRNA interference mediated by lentivirus and CRISPR/Cas9 techniques, we generated knockdown and/or knockout models for these genes. We are now assessing the effect of gene deletion using a multi technique approach, combining 3D reconstruction, electrophysiology and behavioral tests. Acknowledgements D.K.. was supported by a Research Fellow grant of the Fonds National de la Recherche Scientifique (FRS-FNRS) (Belgium). Keywords: Striatum, striatopallidal pathway, cell-type-specific gene, knockdown model, striatonigral pathway Conference: 12th National Congress of the Belgian Society for Neuroscience, Gent, Belgium, 22 May - 22 May, 2017. Presentation Type: Poster Presentation Topic: Cognition and Behavior Citation: Karadurmus D, Rial D, De Kerchove D'Exaerde A and Schiffmann SN (2019). Functional role of new striatopallidal specific genes in motor and motivational behavior. Front. Neurosci. Conference Abstract: 12th National Congress of the Belgian Society for Neuroscience. doi: 10.3389/conf.fnins.2017.94.00074 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 24 Apr 2017; Published Online: 25 Jan 2019. * Correspondence: Ms. Deniz Karadurmus, Université Libre de Bruxelles, Brussels, Belgium, denizkaradurmus@hotmail.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Deniz Karadurmus Daniel Rial Alban De Kerchove D'Exaerde Serge N Schiffmann Google Deniz Karadurmus Daniel Rial Alban De Kerchove D'Exaerde Serge N Schiffmann Google Scholar Deniz Karadurmus Daniel Rial Alban De Kerchove D'Exaerde Serge N Schiffmann PubMed Deniz Karadurmus Daniel Rial Alban De Kerchove D'Exaerde Serge N Schiffmann Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.