Abstract
PurposeThe aim of this study was to compare functional data of different nerve-gap bridging materials evaluated in rat experiments by means of a systematic review.Materials and methodsA systematic review was conducted, searching MEDLINE, HTS and CENTRAL to identify all trials evaluating functional recovery of artificial nerve conduits in the rat model.ResultsThere was a trend towards a favourable outcome of conduits coated with Schwann-cells compared to the plain synthetics. Histomorphometry, electrophysiology and muscle-weight correlated poorly with functional outcome.ConclusionSchwann-cell coated conduits showed promising results concerning functional recovery. Further standardization in outcome reporting is encouraged.
Highlights
Peripheral nerve injury is common in trauma patients, since, 4.5% of all soft-tissue injuries are accompanied by defects of peripheral nerves [1]
Artificial nerve conduits are in evaluation, mainly in animal models
Functional assessments Ten of 12 studies used the sciatic functional index (SFI) as a parameter for functional limb recovery, 1 study by Piquillod used the peroneal score [5], the study of our group performed on median nerve utilized a grasp test [6]
Summary
Peripheral nerve injury is common in trauma patients, since, 4.5% of all soft-tissue injuries are accompanied by defects of peripheral nerves [1]. Despite the well-known benefits of nerve grafting, donor site morbidity must be taken into consideration. To solve this problem, artificial nerve conduits are in evaluation, mainly in animal models. Different nerves (i.e. median nerve, sciatic nerve, facial nerve, etc.) were used in the past to demonstrate the efficacy of numerous materials and concepts (resorbable vs non-resorbable, cellular vs acellular, etc.). This plenty of different experimental studies in the rat were conducted with different techniques, materi-
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Journal of Brachial Plexus and Peripheral Nerve Injury
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
