Functional properties of parathyroid hormone receptors in kidney and bone.

Abstract

It is well established that the renal and skeletal actions of parathyroid hormone (PTH) contribute to the maintenance of calcium and phosphate homeostasis. Considerable evidence exists for the involvement of cAMP in mediating some of the effects of PTH in the kidney: 1) in vivo administration of the hormone rapidly increases urinary cAMP and subsequently induces phosphaturia1; 2) cAMP mimics this response1,2; and 3) renal plasma membranes contain PTH-responsive adenylate cyclase activity3. The role of cAMP in PTH regulation of bone metabolism is less clear. Although it has been shown that PTH stimulates production of cAMP in whole bone4 and in cultured bune cells5, evidence exists both for and against the involvement of cAMP in PTH-induced bone resorption, osteocytic osteolysis, inhibition of bone formation, and skeletal lactate production6.KeywordsParathyroid HormoneAdenylate CyclaseBone CellForward Rate ConstantStimulate cAMP ProductionThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.