Abstract
Assigning functional information to hypothetical proteins in virus genomes is crucial for gaining insight into their proteomes. Human adenoviruses are medium sized viruses that cause a range of diseases. Their genomes possess proteins with uncharacterized function known as hypothetical proteins. Using a wide range of protein function prediction servers, functional information was obtained about these hypothetical proteins. A comparison of functional information obtained from these servers revealed that some of them produced functional information, while others provided little functional information about these human adenovirus hypothetical proteins. The PFP, ESG, PSIPRED, 3d2GO, and ProtFun servers produced the most functional information regarding these hypothetical proteins.
Highlights
Human adenoviruses (HAdVs) are double stranded DNA viruses that are around 35 kb in size [1]
There are 7 species of human adenoviruses, species A-G which are further divided into different strains/types increasingly based on bioinformatics and genomics approaches due to the availability of whole genome sequences, whereas earlier, this was done based on serum neutralization and hemagglutination inhibition [5]
We found that some of these servers provided little to no information about the function of these HAdV hypothetical proteins, while others provided information that could potentially be used by wet bench biologists to further experimentally characterize these proteins
Summary
Human adenoviruses (HAdVs) are double stranded DNA viruses that are around 35 kb in size [1]. These viruses cause a wide variety of diseases such as acute respiratory disease [2], keratoconjunctivitis [3], and gastroenteritis [4]. In order to better understand the genomes to which these proteins belong, it will be extremely helpful to assign functions to these hypothetical proteins. Even with their relatively small genome size compared with prokaryotes and eukaryotes, HAdVs possess several hypothetical proteins that need to be functionally annotated
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