Abstract
Objective. The aim of this study was to investigate the association of functional MMP-1-1607 1G/2G and MMP-9-1562 C/T gene polymorphisms with spontaneous preterm birth (SPTB; preterm birth with intact membranes) in European Caucasian women, as well as the contribution of these polymorphisms to different clinical features of women with SPTB. Methods and Patients. A case-control study was conducted in 113 women with SPTB and 119 women with term delivery (control group). Genotyping of MMP-1-1607 1G/2G and MMP-9-1562 C/T gene polymorphisms was performed using the combination of polymerase chain reaction and restriction fragment length polymorphism methods. Results. There were no statistically significant differences in the distribution of neither individual nor combinations of genotype and allele frequencies of MMP-1-1607 1G/2G and MMP-9-1562 C/T polymorphisms between women with SPTB and control women. Additionally, these polymorphisms do not contribute to any of the clinical characteristics of women with SPTB, including positive and negative family history of SPTB, gestational age at delivery, and maternal age at delivery, nor fetal birth weight. Conclusion. We did not find the evidence to support the association of MMP-1-1607 1G/2G and MMP-9-1562 C/T gene polymorphisms with SPTB in European Caucasian women.
Highlights
Preterm birth (PTB) is a common complication of pregnancy and an important perinatal health problem, occurring in 9.6% of all births worldwide [1]
Genotyping of matrix metalloproteinases (MMP)-1-1607 1G/2G and MMP-9-1562 C/T gene polymorphisms was performed using the combination of polymerase chain reaction and restriction fragment length polymorphism methods
We did not find the evidence to support the association of MMP-1-1607 1G/2G and MMP-9-1562 C/T gene polymorphisms with spontaneous preterm birth (SPTB) in European Caucasian women
Summary
Preterm birth (PTB) is a common complication of pregnancy and an important perinatal health problem, occurring in 9.6% of all births worldwide [1]. Preterm birth can be the consequence of three conditions, including preterm premature rupture of membranes (PPROM), medical indications, or preterm labor with intact membranes (spontaneous PTB; SPTB) [3, 4]. The latter accounts for almost 50% of all cases of PTB [1, 3, 4]. The first group comprises genes encoding products involved in host response to infection and inflammation, whereas the products of genes in the second group participate in extracellular matrix (ECM) remodeling
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
