Abstract
OPINION article Front. Neurol., 08 April 2015Sec. Multiple Sclerosis and Neuroimmunology Volume 6 - 2015 | https://doi.org/10.3389/fneur.2015.00079
Highlights
While the first hypothesis is extremely difficult to test in vivo – even applying advanced structural MRI techniques such as diffusion tensor imaging (DTI) – the second hypothesis has been repeatedly tested by functional MRI during visual stimuli or, more recently, resting conditions
In order to explore the effect of previous optic neuritis (ON) on intrinsic visual RS network (V-RSN) connectivity, we investigated a population of 30 RRMS patients [16 without and with (ON-Multiple sclerosis (MS)) previous ON] and healthy controls (HCs) [13]
Relevant cortical functional changes have been consistently described at the level of striate and extra-striate areas using either photic-stimulated or RS-functional MRI (fMRI) studies
Summary
While the first hypothesis is extremely difficult to test in vivo – even applying advanced structural MRI techniques such as diffusion tensor imaging (DTI) – the second hypothesis has been repeatedly tested by functional MRI (fMRI) during visual stimuli or, more recently, resting conditions. Using visual-stimulated fMRI, MS patients in the early stages of ON have consistently shown a reduced response to visual stimuli in the primary visual (striate) cortex when compared to healthy controls (HCs) [4,5,6].
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