Abstract
AbstractPure pancreatic β cells play a major role in multiple areas of diabetic research, nevertheless, the separation of β cells remains a challenge. The objective of this study is to show the feasibility of using plasma polymers to remove fibroblasts from β cells. Oxygen‐ and nitrogen‐rich organic coatings with different O and N concentrations were prepared by plasma copolymerization of binary gas mixtures combining a hydrocarbon and a heteroatom‐containing gas. The separation of cell pancreatic and fibroblast cell lines was tested using various plasma polymers. The results showed that a unique oxygen‐rich coating with ∼13% of oxygen, promoted fibroblast separation with 82% selectivity. The results support the concept that plasma polymers could be a suitable substrate for the selective adhesion and removal of fibroblasts.
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