Functional Parameters of 18F-FDG PET/CT in Patients with Primary Testicular Diffuse Large B-Cell Lymphoma

Jing Yang,Miao Xu,Yiting Dong,Jianqi Hao,Xuelei Ma,Fuwen Pang,Sha Zhu

doi:10.1155/2018/8659826

Jing Yang, Miao Xu + Show 5 more

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https://doi.org/10.1155/2018/8659826

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Abstract

Fluorine-18 fluorodeoxyglucose (18F-FDG) positron-emission tomography/computed tomography (PET/CT), a hybrid imaging technique that simultaneously provides functional and anatomical information, has been reported to be useful in lymphoma. The present study was to evaluate the functional parameters of 18F-FDG PET/CT in patients with testicular diffuse large B-cell lymphoma (DLBCL). We retrospectively reviewed medical records of 5095 patients with lymphoma who treated at West China Hospital between March 2003 and January 2017, and selected patients with 18F-FDG PET/CT findings and subsequently biopsy confirmed the invasion of testis with DLBCL. Maximum standardized uptake values (SUVmax), peak standardized uptake values (SUVpeak), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) of the patients were measured. We evaluated the characteristics of 18F-FDG PET/CT in this population. Six patients ranged in age from 37 to 73 years (median age, 58 years) were included in the analysis. The mean SUVmax was 11.09 and varied between 7.20 and 19.75; mean SUVpeak was 9.56 and ranged between 6.79 and 14.39. In addition, mean MTV 42% was 18.4 and varied between 1.3 and 61.6; mean MTV 2.5 was 34.7 and varied significantly between 1.6 and 141.9. With regard to TLG, mean TLG 42% was 168.906 and ranged from 7.514 to 687.004, while mean TLG 2.5 was 253.972 and ranged from 8.400 to 1127.802. In conclusion, 18F-FDG PET/CT scan is a useful tool in patients with testicular DLBCL. SUV, MTV, and TLG may vary a lot in different patients. SUVmax of testicular DLBCL lesion is relatively higher than that of normal testis. Also, we provided a set of MTV and TLG data and firstly showed their significant correlation with overall survival, which indicated a potential prognostic value of MTV and TLG. However, studies with larger population are needed to confirm these findings.

Highlights

Testicular lymphoma is a rare but aggressive form of extranodal lymphoma, accounting for 3–9% of testicular cancers and 1-2% of non-Hodgkin’s lymphomas [1, 2]
Five (83.3%) out of 6 patients were classified clinically as stage IVB, and 1 (16.7%) as stage IEA according to the Ann Arbor classification. e International Prognostic Index (IPI) score of patients were calculated, and the results revealed that 5 patients (83.3%) had a score of 3 while 1 patient (16.7%) had a score of 1
We firstly focused on the use of 18F-FDG positronemission tomography/computed tomography (PET/computed tomography (CT)) in the prognosis and staging of patients with testicular di use large B-cell lymphoma (DLBCL) and reported their SUVmax, SUVmean, SUVpeak, metabolic tumor volume (MTV), and total lesion glycolysis (TLG)

Summary

Introduction

Testicular lymphoma is a rare but aggressive form of extranodal lymphoma, accounting for 3–9% of testicular cancers and 1-2% of non-Hodgkin’s lymphomas [1, 2]. In spite of the low overall incidence, testicular lymphoma is the most common testicular malignancy in men over 60 [2]. Testicular di use large B-cell lymphoma (DLBCL) is the most common histological subtype, accounting for about 80% to 98% of all cases [3]. Other diagnostic methods include testicular ultrasound, computed tomography (CT), routine blood test, lactate dehydrogenase, bone marrow biopsy, and lumbar puncture [5]. Fluorine-18 uorodeoxyglucose (18F-FDG) positronemission tomography/computed tomography (PET/CT) is a hybrid imaging technique that simultaneously provides functional and anatomical information. 18F-FDG PET/CT is important in biomedical research and clinical diagnostics, and its application in lymphoma has already been reported [6, 7]. Fluorine-18 uorodeoxyglucose (18F-FDG) positronemission tomography/computed tomography (PET/CT) is a hybrid imaging technique that simultaneously provides functional and anatomical information. 18F-FDG PET/CT is important in biomedical research and clinical diagnostics, and its application in lymphoma has already been reported [6, 7]. ere are several parameters being repeatedly

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