Abstract
Functional ovarian reserve in women with infertility and euthyroidism: what is the role of thyroid autoimmunity?
Highlights
Thyroid dysfunction is the most common endocrine disorder in women of childbearing age, and is associated with menstrual irregularities, anovulation and infertility
Anti-thyroid peroxidase (TPO) antibodies were positive in 11.0% of patients and anti-TG antibodies in 7.0%
In the univariate and multivariate analysis, only patient's age and antral follicle count (AFC) were predictive of anti-Müllerian hormone (AMH) levels (p
Summary
Thyroid dysfunction is the most common endocrine disorder in women of childbearing age, and is associated with menstrual irregularities, anovulation and infertility Whether it is thyroid function, thyroid autoimmunity (AI) or both that affects functional ovarian reserve remains to be clarified. Several studies indicate that ovarian function is adversely affected and frequency of miscarriages and infertility are increased in women with autoimmune thyroid diseases [6, 7]. These observations can be explained by the presence of thyroid hormone receptors on oocytes suggesting that thyroid hormones may influence ovarian functions [8]. It is proposed that anti-TPO antibodies pass through the blood follicle barrier during follicular development which can damage the growing follicles and oocytes [9]
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