Functional Organization of Squirrel Monkey Primary Auditory Cortex: Responses to Frequency-Modulation Sweeps

Abstract

The squirrel monkey twitter call is an exemplar of a broad class of species-specific vocalizations that contain naturally voiced frequency-modulated (FM) sweeps. To investigate how this prominent communication call element is represented in primary auditory cortex (AI), neuronal receptive field properties to pure-tone and synthetic, logarithmically spaced FM-sweep stimuli in 3 barbiturate-anesthetized squirrel monkeys are studied. Responses to pure tones are assessed by using standard measures of frequency response areas, whereas responses to FM sweeps are classified according to direction selectivity, best speed, and speed tuning preferences. Most neuronal clusters respond to FM sweeps in both directions and over a range of FM speeds. Center frequencies calculated from the average of high and low trigger frequency edges of FM response profiles are highly correlated with pure-tone characteristic frequencies (CFs). However, bandwidth estimates are only weakly correlated with their pure-tone counterparts. CF and direction selectivity are negatively correlated. Best speed maps reveal idiosyncratically positioned spatial aggregation of similar values. In contrast, direction selectivity maps show unambiguous spatial organization. Neuronal clusters selective for upward-directed FM sweeps are located in ventral-caudal AI, where CFs range from 0.5 to 1 kHz. Combinations of pure-tone and FM response parameters form 2 significant factors to account for response variations. These results are interpreted in the context of earlier FM investigations and neuronal encoding of dynamic sounds.