Abstract
Transient intrinsic optical signal (IOS) changes have been observed in retinal photoreceptors, suggesting a unique biomarker for eye disease detection. However, clinical deployment of IOS imaging is challenging due to unclear IOS sources and limited signal-to-noise ratios (SNRs). Here, by developing high spatiotemporal resolution optical coherence tomography (OCT) and applying an adaptive algorithm for IOS processing, we were able to record robust IOSs from single-pass measurements. Transient IOSs, which might reflect an early stage of light phototransduction, are consistently observed in the photoreceptor outer segment almost immediately (<4 ms) after retinal stimulation. Comparative studies of dark- and light-adapted retinas have demonstrated the feasibility of functional OCT mapping of rod and cone photoreceptors, promising a new method for early disease detection and improved treatment of diseases such as age-related macular degeneration (AMD) and other eye diseases that can cause photoreceptor damage.
Highlights
Transient intrinsic optical signal (IOS) changes have been observed in retinal photoreceptors, suggesting a unique biomarker for eye disease detection
Comparative studies of dark- and light-adapted retinas have demonstrated the feasibility of functional optical coherence tomography (OCT) mapping of rod and cone photoreceptors, promising a new method for early disease detection and improved treatment of diseases such as age-related macular degeneration (AMD) and other eye diseases that can cause photoreceptor damage
M any eye diseases, such as age-related macular degeneration (AMD), retinitis pigmentosa (RP), glaucoma and diabetic retinopathy (DR), can produce retinal damage that is associated with severe vision loss including legal blindness
Summary
Transient intrinsic optical signal (IOS) changes have been observed in retinal photoreceptors, suggesting a unique biomarker for eye disease detection. Comparative studies of dark- and light-adapted retinas have demonstrated the feasibility of functional OCT mapping of rod and cone photoreceptors, promising a new method for early disease detection and improved treatment of diseases such as age-related macular degeneration (AMD) and other eye diseases that can cause photoreceptor damage. Functional evaluation of the physiological integrity of retinal cells is important for early disease detection and reliable treatment management Psychophysical methods, such as Amsler grid test, visual acuity[3,4] and hyperacuity perimetry[5], are practical in clinical applications, but they involve extensively higher order cortical processing. Comparative studies of dark- and light-adapted retinas demonstrate the feasibility of functional OCT mapping of rod and cone photoreceptors
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