Functional Non-coding RNA During Embryonic Myogenesis and Postnatal Muscle Development and Disease.

Hongmei Luo,Zaiyan Xu,Qian Tong,Bo Zuo,Jianjun Jin,Wei Lv

doi:10.3389/fcell.2021.628339

Abstract

Skeletal muscle is a highly heterogeneous tissue that plays a crucial role in mammalian metabolism and motion maintenance. Myogenesis is a complex biological process that includes embryonic and postnatal development, which is regulated by specific signaling pathways and transcription factors. Various non-coding RNAs (ncRNAs) account for the majority of total RNA in cells and have an important regulatory role in myogenesis. In this review, we introduced the research progress in miRNAs, circRNAs, and lncRNAs related to embryonic and postnatal muscle development. We mainly focused on ncRNAs that regulate myoblast proliferation, differentiation, and postnatal muscle development through multiple mechanisms. Finally, challenges and future perspectives related to the identification and verification of functional ncRNAs are discussed. The identification and elucidation of ncRNAs related to myogenesis will enrich the myogenic regulatory network, and the effective application of ncRNAs will enhance the function of skeletal muscle.

Highlights

Skeletal muscle is a highly heterogeneous tissue that contains myofibers, the basement membrane, muscle satellite cells, immunocytes, and nerves, and plays a crucial role in locomotion, metabolism, and homeostasis
We mainly focused on the importance of miRNAs, circRNAs, and lncRNAs in embryonic myogenesis and postnatal skeletal muscle development, and discussed their regulation of muscle disease
Most researchers have used overexpression or inhibition of ncRNA function to explore their mechanisms during myogenesis; some ncRNAs have been well-investigated using in vivo mouse models

Summary

Introduction

Skeletal muscle is a highly heterogeneous tissue that contains myofibers, the basement membrane, muscle satellite cells, immunocytes, and nerves, and plays a crucial role in locomotion, metabolism, and homeostasis. We mainly focused on ncRNAs that regulate myoblast proliferation, differentiation, and postnatal muscle development through multiple mechanisms. We mainly focused on the importance of miRNAs, circRNAs, and lncRNAs in embryonic myogenesis and postnatal skeletal muscle development, and discussed their regulation of muscle disease.

Results

Conclusion