Abstract
.Significance: Deficits in sensorimotor function in persons with type II diabetes mellitus (PwDM) have traditionally been considered a result of peripheral nerve damage. Emerging evidence has suggested that factors outside of nerve damage due to type II diabetes mellitus, such as impaired hemodynamic function, contribute significantly to both sensory and motor deficits in PwDM.Aim: The focus of the current study was to evaluate functional cortical hemodynamic activity during sensory and motor tasks in PwDM.Approach: Functional near-infrared spectroscopy was used to monitor oxyhemoglobin (HbO) and deoxyhemoglobin (HbR) across the cortex during sensory and motor tasks involving the hands.Results: Decline in HbO across sensory and motor regions of interest was found in PwDM with simultaneous deficits in manual motor tasks, providing the first evidence of functional cortical hemodynamic activity deficits relating to motor dysfunction in PwDM. Similar deficits were neither specifically noted in HbR nor during evaluation of sensory function. Health state indices, such as , blood pressure, body mass index, and cholesterol, were found to clarify group effects.Conclusions: Further work is needed to clarify potential sex-based differences in PwDM during motor tasks as well as the root of reduced cortical HbO indices but unchanged HbR indices in PwDM.
Highlights
24% of the 40 million individuals in the United States over the age of 60 are currently living with type II diabetes mellitus (DM).[1]
Decline in HbO across sensory and motor regions of interest was found in Persons with DM (PwDM) with simultaneous deficits in manual motor tasks, providing the first evidence of functional cortical hemodynamic activity deficits relating to motor dysfunction in PwDM
We considered the interaction between the experimental condition and the group (DM versus control) as the fixed effect contributing to the weight coefficient, while the magnitude of the coefficient of individual subjects was considered as a random effect
Summary
24% of the 40 million individuals in the United States over the age of 60 are currently living with type II diabetes mellitus (DM).[1] Persons with DM (PwDM) experience decline in hand/finger sensorimotor function as compared to healthy individuals;[2,3,4] selfawareness of these changes is low.[5] Reduced functional hand use has been associated with a loss of independent living and reduced quality of life in PwDM.[6,7] Tactile dysfunction due to peripheral neuropathy (PN) has been implicated as the primary cause of motor deficits in. Downloaded From: https://www.spiedigitallibrary.org/journals/Neurophotonics on 08 Nov 2021. Due to the confluence of multiple systemic changes in the body in PwDM, the contribution of impaired or altered cortical function to sensorimotor dysfunction prior to PN diagnosis in PwDM is fully plausible
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