Abstract
OPINION article Front. Neurosci., 27 March 2014Sec. Neurogenesis https://doi.org/10.3389/fnins.2014.00055
Highlights
After two decades of research, the neurosciences have come a long way from accepting that neural stem/progenitor cells (NSPCs) generate new neurons in the adult mammalian hippocampus to unraveling the functional role of adult-born neurons in cognition and emotional control
MAMtreated and focally irradiated mice showed impairments in hippocampus-dependent trace-conditioning and certain forms of long-term spatial memory (Shors et al, 2001; Snyder et al, 2005; Deng et al, 2009), suggesting that adult hippocampal neurogenesis (AHN) was required for particular aspects of learning and memory
FUNCTIONAL HIPPOCAMPAL NEUROGENESIS AND EVOLVING METHODOLOGY Significant advances in conditional gene targeting allowing the generation of transgenic mice and virus-based approaches enabled the selective targeting of adult hippocampal NSPCs and their neuronal progeny, and revealed the molecular pathways important for the different stages of neurogenesis, and specific behavioral correlates of altered AHN (Saxe et al, 2006; Dupret et al, 2008; Jessberger et al, 2009; Deng et al, 2010; Ming and Song, 2011)
Summary
After two decades of research, the neurosciences have come a long way from accepting that neural stem/progenitor cells (NSPCs) generate new neurons in the adult mammalian hippocampus to unraveling the functional role of adult-born neurons in cognition and emotional control. MAMtreated and focally irradiated mice showed impairments in hippocampus-dependent trace-conditioning and certain forms of long-term spatial memory (Shors et al, 2001; Snyder et al, 2005; Deng et al, 2009), suggesting that AHN was required for particular aspects of learning and memory.
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