Abstract
Glutathione functionalized magnetic 3D covalent organic frameworks combined with molecularly imprinted polymer (magnetic 3D COF–GSH MIPs) were developed for the selective recognition and separation of bovine serum albumin (BSA). Ultrasonication was used to prepare magnetic 3D COFs with high porosity (~1 nm) and a large surface area (373 m2 g−1). The magnetic 3D COF–GSH MIP nanoparticles had an imprinting factor of 4.79, absorption capacity of 429 mg g−1, magnetic susceptibility of 32 emu g−1, and five adsorption–desorption cycles of stability. The proposed method has the advantages of a shorter equilibrium absorption time (1.5 h), higher magnetic susceptibility (32 emu g−1), and larger imprinting factor (4.79) compared with those reported from other studies. The magnetic 3D COF–GSH MIPs used with BSA had selectivity factors of 3.68, 2.76, and 3.30 for lysozyme, ovalbumin, and cytochrome C, respectively. The successful recognition and separation of BSA in a real sample analysis verified the capability of the magnetic 3D COF–GSH MIP nanoparticles.
Highlights
Covalent organic frameworks (COFs) are emerging porous crystalline polymers, constructed by combining light elements (e.g., B, C, Si, N, and O) through strong covalent bonds (e.g., B–O, C–N, C=N, and C=C–N), forming static ordered organic building blocks with pores of a precise size [1]
These results indicated that the magnetic 3D COF–GSH molecularly imprinted polymers (MIPs) recognized bovine serum albumin (BSA), but the process of BSA adsorption by the magnetic 3D COF–GSH nonimprinted polymers (NIPs) remained nonspecific (L6)
This study proposed a simple and fast synthesis of magnetic 3D COFs through ultrasonication
Summary
Covalent organic frameworks (COFs) are emerging porous crystalline polymers, constructed by combining light elements (e.g., B, C, Si, N, and O) through strong covalent bonds (e.g., B–O, C–N, C=N, and C=C–N), forming static ordered organic building blocks with pores of a precise size [1]. Studies have reported that COFs exhibit unique properties, such as ordered channels, a large specific surface area, highly tunable structure, and good thermal and chemical stability, leading to their outstanding performance in multiple fields, including energy conversion and storage [2], separation [3,4], gas adsorption [5], catalysis [6], and sensing [7]. Due to their unique photoelectric properties, COFs are demonstrating their potential as a platform for use in the biomedical field, such as for drug delivery, sterilization, bioimaging, and theranostics [8,9,10].
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