Functional Nanoparticles for Molecular Imaging-Guided Gene Delivery and Therapy

Abstract

The inefficient delivery of genes to target tissues and the inability to monitor delivery of genes and therapeutic responses at both cellular and tissue level hinder the success of gene therapy. Fortunately, molecular imaging strategy provides a vital role in assisting gene therapy in a noninvasive and spatiotemporal manner. To better optimize the effectiveness of gene therapy, numerous functional nanoparticles have been developed to achieve this goal while visualizing the delivery process. This chapter provides an overview of various functionalized nanoparticles with unique physiochemical properties for molecular imaging-guided gene therapy.