Abstract
Background: Recent evidence shows that functional magnetic resonance imaging (fMRI) can detect activation in white matter (WM). Such advances have important implications for understanding WM dysfunction. A key step in linking neuroimaging advances to the evaluation of clinical disorders is to examine whether WM activation can be detected at the individual level during clinical tests associated with WM function. We used an adapted Symbol Digit Modalities Test (SDMT) in a 4T fMRI study of healthy adults.Results: Results from 17 healthy individuals revealed WM activation in 88% of participants (15/17). The activation was in either the corpus callosum (anterior and/or posterior) or internal capsule (left and/or right).Conclusions: The findings link advances in fMRI to an established clinical test of WM function. Future work should focus on evaluating patients with WM dysfunction.
Highlights
The ability to measure functional magnetic resonance imaging activation in white matter (WM) using blood oxygen level dependent (BOLD) contrast has potential to advance the clinical investigation of WM disorders
The findings link advances in functional magnetic resonance imaging (fMRI) to an established clinical test of WM function
The current study evaluated whether the adapted Symbol Digit Modalities Test (SDMT) elicited WM fMRI activation in healthy controls
Summary
The ability to measure functional magnetic resonance imaging (fMRI) activation in white matter (WM) using blood oxygen level dependent (BOLD) contrast has potential to advance the clinical investigation of WM disorders (e.g., multiple sclerosis, diffuse axonal injury resulting from brain trauma). A key step in this respect is to examine whether neuropsychological tests that are associated with WM dysfunction can elicit WM fMRI activation at the individual level. Recent evidence shows that functional magnetic resonance imaging (fMRI) can detect activation in white matter (WM). Such advances have important implications for understanding WM dysfunction. A key step in linking neuroimaging advances to the evaluation of clinical disorders is to examine whether WM activation can be detected at the individual level during clinical tests associated with WM function. We used an adapted Symbol Digit Modalities Test (SDMT) in a 4T fMRI study of healthy adults
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