Abstract
The hypothalamo-hypophyseal neurosecretory system (HHNS) of intact and benzene- and xylol-poisoned rats on the 15th day of postnatal life shows changes neither in the content of the neurosecretory material (NSM), nor in the size of the cell nuclei, nucleoli, or cytoplasm. The relative temporal refractoriness of the HHNS in this period suggests that the system has not achieved a complete functional maturity by this time. The quantity and distribution of NSM in the neurosecretory centers and in the neurohypophysis of poisoned 1-month-old rats was distinctly different from that observed in the controls of the same age and mature rats. The decrease of secretory activity of the HHNS parallels that of the sex glands. A delay in the development of sex function was noted in experimental rats. Long-term poisoning in sexually mature rats was accompanied by obvious activation of the HHNS. An evident increase of nuclear volumes of cells in the arcuate and ventromedial nuclei compared with the cells of the suprachiasmatic nucleus was seen in the sexually mature animals. The data obtained speak for a selective sensitivity of the studied magnocellular and parvocellular nuclei to changes in the circulatory level of sex steroids. The effects of benzene and xylol cause various changes in the functional activity of the HHNS and in the sex glands at different stages of postnatal ontogenesis, and the changes found in the HHNS seem to be of an adaptive nature.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
