Abstract
The effect of whole body x-irradiation on macrophage activity was evaluated by in vitro C3b-receptor-mediated ingestion and in vivo carbon clearance. Peritoneal macrophages from B/sub 6/D/sub 2/F/sub 1/ mice were tested from 20 min to 24 hr postirradiation and at doses up to 1000 rad x-irradiation. When compared to peritoneal macrophages from normal unstimulated mice, whole-body irradiation produced an increase in macrophage activity in both C3b-mediated ingestion and carbon clearance. The enhancement of macrophage activity was optimal at an exposure of 200 rad and waned as the exposure dose increased. Enhanced activity appeared as early as 20 min postirradiation and peaked by 3 hr.
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Schedule a callMore From: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
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