Abstract
ABSTRACTFunctional data analysis, which analyzes data that can be represented by curves or images, has many potential applications in clinical trials. Motivated by a real example, this study constructs a functional mixed effects model for analyzing a clinical outcome that is observed continuously over a long period of time. A penalized spline (P-spline)-based method is applied to obtain the estimators of the mean function and the time-varying coefficients. Simulation studies are conducted to investigate the consistency, efficiency, and robustness of the method. To illustrate the use of the method, a real data analysis is performed and produces interpretable results.
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