Abstract
The role of malate dehydrogenase 2 (MDH2) in tumors is double-sided, it has a cancer-promoting effect in some tumors and an inhibitory effect in other tumors. The function of MDH2 is related to energy metabolism, tumor resistance and its pseudo hypoxia. MDH2 plays an important role in the occurrence, development, invasion and metastasis of tumors. An in-depth understanding of the functional mechanism of MDH2 in tumors can provide new molecular targets for tumor intervention in the clinic. Key words: Oxidoreductases; Neoplasms; Malate dehydrogenase 2
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