Functional Interactions Between lncRNAs/circRNAs and miRNAs: Insights Into Rheumatoid Arthritis.

Juan-Juan Han,Xue-Qiang Wang,Xin-An Zhang

doi:10.3389/fimmu.2022.810317

Abstract

Rheumatoid arthritis (RA) is one of the most common autoimmune diseases that affect synovitis, bone, cartilage, and joint. RA leads to bone and cartilage damage and extra-articular disorders. However, the pathogenesis of RA is still unclear, and the lack of effective early diagnosis and treatment causes severe disability, and ultimately, early death. Accumulating evidence revealed that the regulatory network that includes long non-coding RNAs (lncRNAs)/circular RNAs (circRNAs), micro RNAs (miRNAs), and messenger RNAs (mRNA) plays important roles in regulating the pathological and physiological processes in RA. lncRNAs/circRNAs act as the miRNA sponge and competitively bind to miRNA to regulate the expression mRNA in synovial tissue, FLS, and PBMC, participate in the regulation of proliferation, apoptosis, invasion, and inflammatory response. Thereby providing new strategies for its diagnosis and treatment. In this review, we comprehensively summarized the regulatory mechanisms of lncRNA/circRNA-miRNA-mRNA network and the potential roles of non-coding RNAs as biomarkers and therapeutic targets for the diagnosis and treatment of RA.

Highlights

Rheumatoid arthritis (RA) is the most common autoimmune diseases with chronic, systemic inflammatory responses; it is characterized by persistent synovitis, bone, cartilage, and joint destruction [1, 2]
Qu et al suggested that circ-AFF2 was up-regulated in synovial tissues and fibroblast-like synoviocytes (FLS) of RA; circ-AFF2 could bind to the micro RNAs (miRNAs) miR-650; it enhances the expression level of downstream target 2’,3’-cyclic nucleotide phosphodiesterase (CNP) and promotes fibroblast−like synoviocyte proliferation, inflammatory response, migration, and invasion [168]
The circular RNA (circRNA) circ-Sirt1 was up-regulated in FLS and MH7A cells; it participates in the inhibition of cell proliferation, promotion of apoptosis, and reduction of inflammation in MH7A by targeting the miR-132-mediated Sirt1 pathway [170]

Summary

Introduction

Rheumatoid arthritis (RA) is the most common autoimmune diseases with chronic, systemic inflammatory responses; it is characterized by persistent synovitis, bone, cartilage, and joint destruction [1, 2]. Disease activity Biomarkers for RA diagnosis shown that the functions of dysregulation circRNAs are involved in regulating synovial inflammation response and cellular biological behavior of RA FLSs, including proliferation, migration, invasion, and apoptosis (Table 5).

Results

Conclusion