Abstract
Hodics T, Cohen LG, Cramer SC. Functional imaging of intervention effects in stroke motor rehabilitation. Objective To assess intervention-specific effects on cortical reorganization after stroke as shown by available functional neuroimaging studies. Data Sources We searched Medline for clinical trials that contained the terms stroke, reorganization, and recovery, as well as either positron-emission tomography and PET, near-infrared spectroscopy and NIRS, single-photon emission tomography and SPECT, or functional magnetic resonance imaging and functional MRI; we reviewed primary and secondary references. Study Selection Articles that reported neuroimaging findings as a result of a specific treatment involving more than 1 subject were included. Data Extraction We included clinical trials that contained the terms stroke, reorganization, and recovery, as well as functional neuroimaging data findings as a result of a specific treatment involving more than 1 subject. Data Synthesis Included studies differed clearly from one another with regard to patient characteristics, intervention protocol, and outcome measures. Most studies used functional magnetic resonance imaging and a motor paradigm. Studies were limited in size. Conclusions Despite the methodologic differences, several common features can be identified based on the reviewed studies. Clinical improvements occurred even late after injury, after subjects were deemed to have reached a recovery plateau. This clinical improvement was accompanied by cortical reorganization that depended on the type of intervention as well as other factors. This review also suggests direction for future research studies.
Highlights
Data Sources: We searched Medline for clinical trials that contained the terms stroke, reorganization, and recovery, as well as either positron-emission tomography and PET, nearinfrared spectroscopy and Near-infrared spectroscopy (NIRS), single-photon emission tomography and SPECT, or functional magnetic resonance imaging and functional MRI; we reviewed primary and secondary references
Clinical improvements occurred even late after injury, after subjects were deemed to have reached a recovery plateau. This clinical improvement was accompanied by cortical reorganization that depended on the type of intervention as well as other factors
The current review focuses on available data on the effects of restorative interventions on functional magnetic resonance imaging– based assessments of brain function in patients with stroke
Summary
To assess intervention-specific effects on cortical reorganization after stroke as shown by available functional neuroimaging studies. Data Sources: We searched Medline for clinical trials that contained the terms stroke, reorganization, and recovery, as well as either positron-emission tomography and PET, nearinfrared spectroscopy and NIRS, single-photon emission tomography and SPECT, or functional magnetic resonance imaging and functional MRI; we reviewed primary and secondary references. Study Selection: Articles that reported neuroimaging findings as a result of a specific treatment involving more than 1 subject were included. Data Extraction: We included clinical trials that contained the terms stroke, reorganization, and recovery, as well as functional neuroimaging data findings as a result of a specific treatment involving more than 1 subject. Most studies used functional magnetic resonance imaging and a motor paradigm.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have