Functional imaging of brown adipose tissue in human.

Abstract

Obesity has become a major public health challenge and an increasing trend is seen in its prevalence worldwide. It is a complex disorder involving an excessive amount of body fat as a result of an energy imbalance leading to caloric overload. Since the discovery of functional brown adipose tissue (BAT) in adult humans, with energy dissipating properties, this thermogenic tissue has thus emerged as an attractive therapeutic target to combat obesity and related cardiometabolic disorders. The advancements in imaging modalities to evaluate organ-specific metabolism in humans is substantially contributing to understand the physiological role of BAT. This review presents an overview of the different imaging approaches implied in BAT assessment, with a special emphasis on adult human BAT. In this context, we also attempted to summarize the developmental origins and physiology of BAT.