Abstract
Digital holographic optical coherence imaging (DHOCI) is a full-frame coherence-gated imaging approach that uses a CCD camera to record and reconstruct a digital hologram from inside tissue. Our recording of digital holograms at the optical Fourier plane has advantages for diffuse targets compared with Fresnel off-axis digital holography. DHOCI is capable of performing functional imaging by using dynamic image speckle as a contrast agent to locate regions of high metabolic activity characterized by high cellular motility. We show strong dynamic speckle difference between three metabolic states of a tumor, and demonstrate that functional imaging in DHOCI can capture motility information with high contrast. We apply functional imaging to track the effect on cell motility by temperature changes or cytoskeletal drugs.
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