Functional hypoglycemia and the hyperventilation syndrome: a clinical study.

Abstract

Article1 May 1955FUNCTIONAL HYPOGLYCEMIA AND THE HYPERVENTILATION SYNDROME: A CLINICAL STUDYW. L. JACK EDWARDS, M.D., WILLIAM F. LUMMUS, M.D.W. L. JACK EDWARDS, M.D.Search for more papers by this author, WILLIAM F. LUMMUS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-42-5-1031 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIntroductionSpontaneous hypoglycemia was first described by Seale Harris1 in 1924, under the name of "hyperinsulinism." More recently, Conn2 has classified the hypoglycemias, naming "functional hyperinsulinism" as including those forms of hypoglycemia not associated with anatomic lesions. The majority of patients in this group have associated anxiety states, with spontaneous hypoglycemic attacks at least one to two hours after meals. The term now commonly used for this disorder is "functional hypoglycemia."This report is concerned with patients having functional hypoglycemia in a series of 866 referred ambulatory patients. Since the hyperventilation syndrome was found to occur concomitantly in more than...Bibliography1. Harris S: Hyperinsulinism and dysinsulinism, J. A. M. A. 83: 729, 1924. CrossrefGoogle Scholar2. Conn JW: The spontaneous hypoglycemias: importance of etiology in determining treatment, J. A. M. A. 115: 1669, 1940. CrossrefGoogle Scholar3. De Costa JM: An irritable heart: a clinical study of a functional cardiac disorder and its consequences, Am. J. M. Sc. 61: 17, 1871. Google Scholar4. Wood P: De Costa's syndrome, Brit. M. J. 1: 767, 805 and 845, 1941. CrossrefMedlineGoogle Scholar5. Friedman MF: Functional cardiovascular disease, 1947, Williams and Wilkins, Baltimore, p. 35. Google Scholar6. Rice RL: Symptom patterns of the hyperventilation syndrome, Am. J. Med. 8: 691, 1950. CrossrefMedlineGoogle Scholar7. ConnConn JWES: Metabolism in organic hyperinsulinism; quantitative studies of variations in rate of combustion of carbohydrate produced by alterations in diet, Arch. Int. Med. 68: 876, 1941. CrossrefGoogle Scholar8. HarrisonFinks TRRM: Glucose deficiency as a factor in the production of symptoms referable to the cardiovascular system, Am. Heart J. 26: 147, 1943. CrossrefGoogle Scholar9. Conn JW: The diagnosis and management of spontaneous hypoglycemia, J. A. M. A. 134: 130, 1947. CrossrefMedlineGoogle Scholar10. NevesFariaFujioka DPCVT: Hyperglicemia e hipoglicemia conseqüentes ā intoxicāo aguda e crônica pelo ālcool etīlico, Rev. Hosp. clín. 5: 115, 1950. Google Scholar11. ConnNewburghJohnsonSheldon JWLHMWJM: Study of the deranged carbohydrate metabolism in chronic infectious hepatitis, Arch. Int. Med. 62: 765, 1938. CrossrefGoogle Scholar12. Kety SS: Circulation and metabolism of the human brain in health and disease, Am. J. Med. 8: 205, 1950. CrossrefMedlineGoogle Scholar13. Conn JW: The advantage of a high protein diet in the treatment of spontaneous hypoglycemia, J. Clin. Investigation 15: 673, 1936. CrossrefMedlineGoogle Scholar14. ThornQuinbyClinton GWJTM: A comparison of the metabolic effects of isocaloric meals of varying composition with special reference to the prevention of postprandial hypoglycemia symptoms, Ann. Int. Med. 18: 913, 1943. LinkGoogle Scholar15. Cannon WB: Mechanism of emotional disturbance of bodily functions, New England J. Med. 198: 877, 1928. CrossrefGoogle Scholar16. RennieHoward TAJE: Hypoglycemia and tension depression, Psychosom. Med. 4: 273, 1942. CrossrefGoogle Scholar17. MalmoSchaguss RBC: Reaction to stress in anxiety and early schizophrenia, Psychosom. Med. 11: 9, 1949. CrossrefMedlineGoogle Scholar18. SoskinMirskyZimmermanHeller SIALMRC: Normal dextrose tolerance curves in the absence of insulin, in the hypophysectomized depancreatized dog, Am. J. Physiol. 114: 648, 1936. CrossrefGoogle Scholar19. LazurusVolk SSBW: Studies on hypoglycemia responsiveness, Metabolism 2: 500, 1954. Google Scholar20. AndersonLong EJA: Hormonal influences on the secretion of insulin, Recent Prog. in Hor. Research 2: 209, 1948. MedlineGoogle Scholar21. Combat stress: front-line view, The Johns Hopkins Magazine 5: 8 (Feb.) 1954. Google Scholar22. DavisWallace HWM: Factors affecting the electroencephalographic changes induced by hyperventilation, Am. J. Physiol. 113: 258, 1941. Google Scholar23. EngelFerrisLogan GLEBM: Hyperventilation: analysis of clinical symptomatology, Ann. Int. Med. 27: 683, 1947. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Birmingham, Alabama*Received for publication September 7, 1954.From the Department of Medicine, Medical College of Alabama, Birmingham, Ala.†Aided by a grant from the Life Insurance Medical Research Fund.‡Work done during the tenure of a National Heart Institute Traineeship, National Institutes of Health, U. S. Public Health Service. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byNutritional Approaches to Behavior ModificationHypoglycemia and convulsions in children following alcohol ingestion 1 May 1955Volume 42, Issue 5Page: 1031-1040KeywordsAnxietyHeartHyperinsulinemiaHypoglycemiaHypoglycemicsLesionsMedical servicesPrevention, policy, and public healthResearch funding ePublished: 1 December 2008 Issue Published: 1 May 1955 PDF downloadLoading ...