Abstract
The application of functional group contributions (τ values) to the understanding of the retention of analytes in high-performance liquid chromatography is examined. Group contributions from a range of analytes are compared and their relationship to Hansch substituent constants (π values) determined. The effects of interactions between groups in polyfunctional analytes and of changes in the organic modifier and composition of the mobile phase are studied and the influence of different stationary phase materials compared. The potential of functional group contribution values for the prediction of relative and absolute retention is examined.
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