Abstract
Addition of endothelin-1 or endothelin-3 to rat renal papillary tubules produced a dose-dependent inhibition of the cAMP response to vasopressin stimulation. The average EC 50 values were 1.1 ± 0.6 and 2.6 ± 1.1 nM, respectively, indicating mediation by an endothelin ET B receptor. Phorbol myristate acetate (1 μM) also inhibited the vasopressin-cAMP response and this inhibition was not additive with that to endothelin, indicating that the endothelin inhibition is mediated by activation of protein kinase C. These findings demonstrate functionally relevant endothelin ET B receptors on renal papillary tubules. Such receptors are a possible target for endothelin-3 produced within the kidney.
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