Abstract
PERFUSATE COLLOIDS, both protein and non-protein, are utilized in the in vitro perfused kidney [ 1, 61. The beneficial effect of the colloid, of course, is to maintain a physiological balance between the Starling forces at the capillaries and thereby to prevent leakage of fluids from the capillaries into the interstitial spaces. Harvey [4] has demonstrated the efficacy of the nonprotein colloid polyvinylpyrrolidone (PVP) in preventing edema and excessive vascular resistance in the isolated dog kidney. Alternative nonprotein colloids include dextran 70 and hydroxyethyl starch (HES). While the physiological role of colloid oncotic pressure in renal vasuclar homeostasis is well established, there remains controversy concerning the effects of colloids on active and passive renal tubular processes [5]. The purpose of this study was to examine both the renal hemodynamic and functional effects of bloodless perfusion of the isolated rabbit kidney with HES and dextran 70.
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