Abstract
<p indent=0mm>Chromosome cohesion is a cellular process in which sister chromatids are held together by a ring-shaped complex cohesin during cell division. Cohesin and its accessory factors consist of chromosome cohesion family proteins that play pivotal roles in cohesion establishment, maintenance, and dissolution. Also, cohesion proteins are involved in DNA damage repair, gene expression, and high-order chromatin organization. To date, the mitotic functions and regulatory mechanisms of chromosome proteins have been extensively studied; however, during meiosis, they are not yet fully understood, especially during the meiosis I stage. In this review, we summarize the diverse functions of chromosome cohesion proteins in various biological events. In particular, during germ cell meiosis, we elucidate their non-canonical roles and discuss the future avenues for research in this field.
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