Abstract
Analysis of the subcellular localization patterns of duplicate genes revealed that protein subcellular adaptation represents a common mechanism for the functional diversification of duplicate genes.
Highlights
Gene duplication is the primary source of new genes with novel or altered functions
Subcellular divergence is common among yeast wholegenome duplicates Using protein localization data (22 compartments; obtained by green fluorescent protein (GFP)-fusion analysis) covering 75% of the S. cerevisiae proteome [15], we established the subcellular localization of proteins encoded by 900 yeast genes, forming 450 pairs of whole-genome duplication (WGD)-derived duplicate genes [17]
For 88 of these protein pairs, we found that the two duplicates are located in at least one different subcellular compartment (Table 1 and Additional data file 1)
Summary
Gene duplication is the primary source of new genes with novel or altered functions. It is known that duplicates may obtain these new functional roles by evolving divergent expression patterns and/or protein functions after the duplication event. Genome Biology 2008, Volume 9, Issue 3, Article R54 Marques et al R54.2 Both copies might be functionally preserved by natural selection if an increase in gene dosage of the ancestral gene is beneficial [2], or if a change of the stoichiometry of proteins in complexes (for example, after whole genome duplication (WGD) events) would be deleterious [3,4]. If both gene copies are preserved after the duplication event, they may functionally diverge in two major ways. A combination of these two scenarios ('subneofunctionalization') was recently proposed [10]
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