Abstract
The effects of gonyautoxins (GTXs) on the neuromuscular system in rabbits were examined. M waves were evoked by electric stimulation on the tibial nerve and recorded mainly from the plantar interosseous muscle. Intravenous administration of GTXs decreased the amplitude and prolonged both latency and duration of M waves, while showed little effect on the motor nerve conduction velocity. These results suggest that GTXs have inhibitory effects on the peripheral neuromuscular system, mainly on the neuromuscular transmission.
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