Functional Coordination among the Golgi Complex, the Centrosome and the Microtubule Cytoskeleton during the Cell Cycle.

Fabiola Mascanzoni,Antonino Colanzi,Roberta Iannitti

doi:10.3390/cells11030354

Fabiola Mascanzoni, Antonino Colanzi + Show 1 more

Open Access

https://doi.org/10.3390/cells11030354

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Abstract

The Golgi complex of mammalian cells is organized in a ribbon-like structure often closely associated with the centrosome during interphase. Conversely, the Golgi complex assumes a fragmented and dispersed configuration away from the centrosome during mitosis. The structure of the Golgi complex and the relative position to the centrosome are dynamically regulated by microtubules. Many pieces of evidence reveal that this microtubule-mediated dynamic association between the Golgi complex and centrosome is of functional significance in cell polarization and division. Here, we summarize findings indicating how the Golgi complex and the centrosome cooperate in organizing the microtubule network for the directional protein transport and centrosome positioning required for cell polarization and regulating fundamental cell division processes.

Highlights

We summarize findings indicating how the Golgi complex and the centrosome cooperate in organizing the microtubule network for the directional protein transport and centrosome positioning required for cell polarization and regulating fundamental cell division processes
The Golgi complex (GC) consists of stacks of flattened cisternae that are laterally bridged by tubular “noncompact” zones that link equivalent cisternae [2] to form a single-copy organelle, the “Golgi ribbon”, which is often located adjacent to the centrosome and the nucleus [3]
CLASP1/2 can tether microtubules, whereas the length of the microtubules is regulated by CAMSAP2 when it associates with end-binding proteins (EBs) proteins

Summary

Introduction

The Golgi complex (GC) is the central organelle of the secretory pathway and is involved in the processing and targeting of lipids and proteins [1]. The GC consists of stacks of flattened cisternae that are laterally bridged by tubular “noncompact” zones that link equivalent cisternae [2] to form a single-copy organelle, the “Golgi ribbon”, which is often located adjacent to the centrosome and the nucleus [3]. Despite this complex organization, the GC can undergo many structural changes in response to specific physiological needs. We review the crucial functional connection of the GC with the microtubule cytoskeleton and the centrosome, focusing on cell polarity and mitosis

Structural Golgi Proteins

The Microtubule Cytoskeleton

Schematic

The Actin Cytoskeleton

The Golgi and Cytoskeleton

Concluding Remarks