Abstract
Objective: fatigue is a common problem in patients with Parkinson's disease (PD) (1). Despite its clinical relevance, our understanding of fatigue pathophysiology is limited due to the frequent overlap with other confounding non motor symptoms (2) and the lack of structural or functional MRI studies. The aim if this study was, using resting-state (RS) fMRI, to investigate the functional correlates of fatigue in a restricted cohort of “drug-naïve” PD patients, with no depression, sleepiness and cognitively unimpaired.
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