Abstract
The present study aims to advance our understanding of MDD by identifying abnormal patterns of functional connectivity in depressed patients when compared to healthy controls. Primary studies using resting-state functional magnetic resonance imaging (rsfMRI) have reported abnormal functional connectivity in the triple network model (i.e., central executive, default mode, and salience network) in major depressive disorder (MDD). It has been proposed that the aberrant connectivity of these large scale networks plays a significant role in the cognitive deficits, emotional dysfunction, and specific symptoms (e.g., anhedonia, rumination, loss of motivation) of MDD.
Published Version
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