Abstract
AbstractBackgroundMigraine attacks are associated with photo‐, phono‐, and osmophobia, which may be caused by different pathophysiological mechanisms because they are not present in all migraineurs.AimHere, we investigated differences in static and dynamic resting‐state functional connectivities between patients with and without photo‐, phono‐, or osmophobia.MethodsSixty‐two women with migraine with/without photo‐, phono‐, or osmophobia underwent 3‐T functional magnetic resonance imaging during the interictal phase. We compared static and dynamic resting‐state functional connectivities using region of interest‐to‐region of interest analysis of 91 cortical, 15 subcortical, and 26 cerebellar areas.ResultsThe static resting‐state functional connectivity analysis showed that patients with photophobia had 18 different significant connectivity pairs, those with phonophobia had 15, and those with osmophobia had significantly higher connectivity between the right cerebellar lobule and brainstem. The dynamic resting‐state functional connectivity analysis showed that patients with photophobia had 16 different significant connectivity pairs, those with phonophobia had eight without main regions, and those with osmophobia had 14. Static and dynamic functional connectivity alterations in patients with phonophobia and osmophobia had no significant overlapping connectivity pairs.ConclusionOur results showed that static and dynamic resting‐state functional connectivities in migraineurs with and without photo‐, phono‐, or osmophobia differed.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
