Abstract
BackgroundSeveral fMRI studies in migraine assessed resting state functional connectivity in different networks suggesting that this neurological condition was associated with brain functional alteration. The aim of present study was to explore the association between cognitive functions and cerebral functional connectivity, in default mode network, in migraine patients without and with aura, during interictal episodic attack.MethodsTwenty-eight migraine patients (14 without and 14 with aura) and 14 matched normal controls, were consecutively recruited. A battery of standardized neuropsychological test was administered to evaluate cognitive functions and all subjects underwent a resting state with high field fMRI examination.ResultsMigraine patients did not show abnormalities in neuropsychological evaluation, while, we found a specific alteration in cortical network, if we compared migraine with and without aura. We observed, in migraine with aura, an increased connectivity in left angular gyrus, left supramarginal gyrus, right precentral gyrus, right postcentral gyrus, right insular cortex.ConclusionOur findings showed in migraine patients an alteration in functional connectivity architecture. We think that our results could be useful to better understand migraine pathogenesis.
Highlights
Several functional magnetic resonance imaging (fMRI) studies in migraine assessed resting state functional connectivity in different networks suggesting that this neurological condition was associated with brain functional alteration
The aim of present study was to explore the association between cognitive functions and cerebral functional connectivity (FC) between MO and migraine with (MA), during interictal episodic attack
Our findings showed an increase of functional connectivity, in MA, in frontal and parietal lobes, in particular in angular, supramarginal gyrus, somatosensory association cortex, postcentral gyrus and primary somatosensory cortex
Summary
Several fMRI studies in migraine assessed resting state functional connectivity in different networks suggesting that this neurological condition was associated with brain functional alteration. The aim of present study was to explore the association between cognitive functions and cerebral functional connectivity, in default mode network, in migraine patients without and with aura, during interictal episodic attack. Migraine is a common episodic neurological disorder with a complex physiopathology. It is characterized by typical unilateral, often severe, pain throbbing with associated features such as hypersensitivity to multiple stimuli, including visual (photophobia), auditory (phonophobia), and sensory (cutaneous allodynia) stimuli during migraine attacks [1]. Neuropsychological studies suggests that migraine affect cognitive functions during attacks and interictal periods [5], even though it is unclear the association between cognitive dysfunctions and migraine. In other cases authorsdescribed the presence of cognitive deficit only after a long disease duration [7, 8]
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