Functional Connectivity Analyses Suggest Shared Molecular Mechanisms Across 12 Neuropsychiatric Mutations, Autism and Schizophrenia

Clara Moreau,Sebastian Urchs,Guillaume Huguet,Hanad Sharmarke,Claudia Modenato,Elise Douard,Ana Dos Santos Silva,David Linden,Paul M Thompson,Sarah Lippe,Carrie Bearden,Anne Maillard,Pierre Bellec,Sebastien Jacquemont

doi:10.1016/j.biopsych.2020.02.1011

Functional Connectivity Analyses Suggest Shared Molecular Mechanisms Across 12 Neuropsychiatric Mutations, Autism and Schizophrenia

Clara Moreau, Sebastian Urchs + Show 12 more

https://doi.org/10.1016/j.biopsych.2020.02.1011

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Journal: Biological psychiatry	Publication Date: May 1, 2020
Citations: 2

Affiliation: Université de Montréal, Montreal Neurological Institute and Hospital, University of Lausanne, Cardiff University, University of Southern California, University of California, Los Angeles, Hôpital Orthopédique de la Suisse Romande

#Copy Number Variants #Factors For Autism Spectrum Disorder + Show 8 more

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Abstract

Copy number variants (CNVs) are among the most highly penetrant risk factors for autism spectrum disorder (ASD) and schizophrenia (SZ). Almost nothing is known about their impact on functional connectivity (FC). As several CNVs confer risk for both ASD and SZ, we hypothesized that CNVs and idiopathic conditions may converge on a smaller set of FC alteration patterns. We aimed to characterize FC dimensions altered across CNVs and idiopathic psychiatric conditions.

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