Abstract
Background HIV-1 virus is a rapidly evolving virus due to genetic variability through its rapid replication, mutation and recombination potential which is a major hurdle in vaccine development. One of the effective ways to modulate HIV-1 infection is to target viral proteins; among the viral proteins, Tat plays a major role in HIV-1 pathogenesis. It activates viral gene expression through TAR interaction. The aim of this study was to characterize genetic and functional variants of Tat exon-1 from HIV-1 patients from North India.
Highlights
HIV-1 virus is a rapidly evolving virus due to genetic variability through its rapid replication, mutation and recombination potential which is a major hurdle in vaccine development
One of the effective ways to modulate HIV-1 infection is to target viral proteins; among the viral proteins, Tat plays a major role in HIV-1 pathogenesis
Full list of author information is available at the end of the article
Summary
HIV-1 virus is a rapidly evolving virus due to genetic variability through its rapid replication, mutation and recombination potential which is a major hurdle in vaccine development. One of the effective ways to modulate HIV-1 infection is to target viral proteins; among the viral proteins, Tat plays a major role in HIV-1 pathogenesis. It activates viral gene expression through TAR interaction. The aim of this study was to characterize genetic and functional variants of Tat exon-1 from HIV-1 patients from North India
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